Hoof wall separation syndrome


Good news!   

Your horse is clear of hoof wall separation syndrome and does not have this gene mutation.   

Your horse cannot pass on this mutation. There are no breeding or performance implications.  

What is hoof wall separation syndrome?

A syndrome that develops in horses during the first year of life and causes the dorsal wall of the hoof to crack and split. In severe cases, the whole dorsal hoof wall breaks away from above the height of the sole and affected horses are forced to stand on the sole without the essential support provided by the hoof wall. 

 While this syndrome is not fatal, it will cause chronic inflammation, severe lameness, and laminitis. Not all cases are acute, and with management through specialist hoof care and protective shoeing, owners can help curtail the intensity of the condition. 

Genomic Details

The mutation that causes hoof wall separation syndrome is an insertion in the SERPINB11 gene. Additional material is added to the gene. Therefore, the instructions from the SERPINB11 gene are abnormal. This leads to separation of the hoof wall. The horse is unable to put its weight onto the hoof, which can lead to laminitis. It’s not certain how this gene causes the disease.

A horse’s genetic result for hoof wall separation syndrome is one of three possibilities:

  • Not inserted / Not Inserted: Does not have the disease. Does not have the mutation.

  • Not inserted / Inserted: Carrier. Does not have the disease. Carries one gene mutation from one parent. This might be passed to their foal.

  • Inserted / Inserted: Affected. Has the genetic disease. The horse has inherited a gene mutation from each parent. One mutation will be passed to their foal.